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Chemotherapy was potentiated by E7449 and one agent had major antitumor activity in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile lines, probable by means of TNKS inhibition. Consistent with this likelihood, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and substantial

System for making ready in vivo formulation：Get μL DMSO grasp liquid, future include μL PEG300， combine and make clear, upcoming add μL Tween 80，mix and clarify, up coming insert μL ddH2O, combine and make clear.The overall similarities exhibited by conventional benzodiazepines entail a baseline risk stage which is typical to all of these